3 Jan 2025 • A recent population-based case-control study revealed that women diagnosed with locally advanced or metastatic breast cancer have a 10% higher incidence of cardiovascular disease (CVD) compared to their counterparts, even after adjusting for factors that could delay cancer diagnosis. The findings highlight a casual relationship between cardiovascular health and cancer, particularly breast cancer.

The study analysed data from 19,292 female participants aged 66 and older diagnosed with invasive breast cancer in which 9478 (49.1%) female participants had prevalent cardiovascular disease. The findings suggest that CVD may have a direct impact on the growth and metastasis of the tumor with supporting evidence from mechanistic studies, particularly murine (mouse) models that cardiovascular conditions such as myocardial infarction (MI) may actively promote tumor development

The association was particularly strongest for hormone receptor-positive, ERBB2-negative breast cancer, a subtype known for its slower progression. This highlights the critical interplay between cardiovascular health and breast cancer, particularly for women with this specific subtype.

The findings align with the past research, namely the Atherosclerosis Risk in Communities study, which showed that having a good cardiovascular health reduces the risk of developing cancer.

The study emphasizes the need for personalized breast screening methods for those with cardiovascular disease to ensure earlier detection of breast cancer and improved outcomes.