29 Jan 2025 • A large, decade-long cohort study found that advanced liver fibrosis is strongly linked to an elevated risk of ischemic stroke, intracerebral hemorrhage, subarachnoid hemorrhage, and higher mortality.

Participants with liver fibrosis, identified using the Fibrosis-4 index, faced higher risks: ischemic stroke (HR 1.94), intracerebral hemorrhage (HR 2.14), subarachnoid hemorrhage (HR 1.90), stroke-related death (HR 2.20), and all-cause mortality (HR 2.59).

Using the aspartate aminotransferase to platelet ratio index, the risk for intracerebral hemorrhage (HR 3.76) and subarachnoid hemorrhage (HR 3.05) was even more pronounced compared to ischemic stroke (HR 1.58).

These findings highlight liver fibrosis as an easily accessible marker for identifying individuals at elevated risk of stroke and mortality, emphasizing its potential role in primary prevention.

Source: AHA Journals | Read Full Story