Chronic Hepatitis B (HBV) management remains a dynamic tightrope walk, where meeting treatment cessation criteria is only half the battle. In this 1st episode of ENHANCE, a case-based learning initiative by Viatris, we delve into the sharp realities of HBV management, viral reactivation, and the silent progression toward Hepatocellular Carcinoma (HCC). Led by renowned Moderator Dr. Yogesh Batra, this interactive episode features two complex, real-world case presentations by leading experts Dr. Akash Shukla and Dr. Anand Kulkarni. Together they will dissect the clinical nuances of viral rebounds, surveillance pitfalls, and the critical role of aggressive tumor biomarkers like PIVKA-II.