A study of 437,465 women with live births (2005–2017) revealed a strong bidirectional link between hyperemesis gravidarum and depression. 

**Key Findings:**
- Among 4,265 women with hyperemesis, 8.8% had pre-pregnancy depression versus 1.0% of 302,663 controls (AOR 5.2). 
- Post-pregnancy depression was also more common (4.9% vs 1.0%; AOR 3.6) and occurred earlier (3.3 vs 4.5 years postpartum), with most cases developing over a year after delivery. 

The findings suggest shared biological pathways between severe pregnancy nausea and depression, emphasizing the need for early psychiatric screening and multidisciplinary care in affected women.

Source: Science Direct | [Read Full Story](https://www.sciencedirect.com/science/article/abs/pii/S2215036625002718?dgcid=rss_sd_all)

Bidirectional Link Between Hyperemesis Gravidarum and Depression Identified

In a study of 712 elderly patients hospitalized with community-acquired pneumonia (CAP), metabolic syndrome (MetS) was linked to significantly worse short-term outcomes. 

**Key Findings:**
- After propensity score matching (n = 336), 90-day mortality was markedly higher in those with MetS (29.8% vs 11.9%). 
- Multivariate analysis confirmed MetS as an independent predictor of death (HR 1.98), and each additional MetS component increased mortality risk 1.46-fold. 

These findings show that MetS nearly doubles death risk in elderly CAP patients, emphasizing the importance of early detection and metabolic optimization to improve survival.

Source: BMC Pulmonary Medicine | [Read Full Story](https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-025-03914-4)

Metabolic Syndrome Doubles Mortality Risk in Elderly Pneumonia Patients

A retrospective study of bladder cancer patients undergoing robot-assisted radical cystectomy with extracorporeal urinary diversion found that a 6-week postoperative renal ultrasound (RUS) was highly effective for detecting ureteroenteric anastomotic strictures (UAS). 

Among 623 renal units, hydronephrosis occurred in 23%, and 17% of these developed UAS, compared with just one case (0.2%) without hydronephrosis. 

The 6-week RUS showed 96% sensitivity, 80% specificity, and 99% negative predictive value, confirming it as a reliable, non-invasive, and cost-effective tool to rule out UAS after cystectomy.

Source: Science Direct | [Read Full Story](https://www.sciencedirect.com/science/article/pii/S1078143925003886?dgcid=rss_sd_all)

Early Renal Ultrasound Reliably Rules Out Post-Cystectomy Strictures

A large cohort study demonstrated a bidirectional link between type 2 diabetes (T2DM) and inflammatory bowel disease (IBD). 

**Key Findings:**
- Among 4921 IBD patients and over 438,000 controls followed for 12.6 years, IBD increased T2DM risk (HR 1.44), with similar trends for ulcerative colitis (HR 1.41) and Crohn’s disease (HR 1.62). 
- Conversely, T2DM raised the risk of IBD (HR 1.40), ulcerative colitis (HR 1.41), and Crohn’s disease (HR 1.48) over 12.9 years. 

Risks rose with greater disease severity in both directions, underscoring shared inflammatory-metabolic pathways and the need for integrated monitoring and prevention.

Source: Journal of Clinical Gastroenterology | [Read Full Story](https://journals.lww.com/jcge/abstract/9900/bidirectional_association_of_type_2_diabetes.523.aspx)

Diabetes and Inflammatory Bowel Disease Found to Fuel Each Other’s Risk

An analysis of over 390,000 adults revealed that atopic dermatitis (AD) was linked to a higher risk of nonmelanoma skin cancer (NMSC) compared with matched controls. 

**Key Findings:**
- The NMSC incidence was 2.12 vs. 1.74 cases per 100 person-years, corresponding to an adjusted hazard ratio of 1.32. 
- The elevated risk persisted in patients with moderate-to-severe AD and was similar when compared with rheumatoid arthritis controls. 
- Those with prior NMSC, malignancy, or organ transplantation faced the greatest risk. 

The findings highlight AD as an independent risk factor for NMSC, underscoring the need for regular dermatologic surveillance.

Source: Springer Nature Link | [Read Full Story](https://link.springer.com/article/10.1007/s13555-025-01559-z)

Atopic Dermatitis Linked to Elevated Nonmelanoma Skin Cancer Risk

A study in preterm infants (<34 weeks) showed that lung ultrasound (LUS)-guided surfactant therapy optimized timing and dosing for neonatal respiratory distress syndrome (NRDS) and transient tachypnea of the newborn (TTN). 

Among NRDS cases assessed within an hour of birth, complete lung re-expansion was achieved in 60.0%, 63.6%, and 75.0% after the first, second, and third Poractant alfa doses, with 96.4% achieving full re-expansion within three doses. 

All TTN infants reached complete recruitment within two doses. LUS proved a reliable, radiation-free tool for individualized and efficient neonatal respiratory management.

Source: Frontiers | [Read Full Story](https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2025.1634955/full)

Ultrasound-Guided Surfactant Therapy Personalizes Respiratory Care in Preterm Infants

An analysis of 929,142 myopic patients found that retinal sequelae of myopia markedly increased the risk of primary open-angle glaucoma (POAG) and its progression. 

**Key Findings:**
- Foveal retinal detachment showed the strongest association (AOR 5.82), followed by foveoschisis (AOR 3.10) and myopic macular degeneration (AOR 2.87). 
- Patients with foveoschisis (HR 5.33), MMD (HR 2.74), macular hole (HR 1.73), choroidal neovascularization (HR 1.73), and rhegmatogenous retinal detachment (HR 1.54) progressed faster from glaucoma suspect to POAG. 

These findings support proactive glaucoma screening in myopic patients with retinal complications to prevent vision loss.

Source: Dovepress | [Read Full Story](https://www.dovepress.com/the-association-between-the-retinal-sequelae-of-myopia-and-glaucoma-in-peer-reviewed-fulltext-article-OPTH)

Retinal Damage in Myopia Signals Higher Glaucoma Risk

A global meta-analysis found that nearly one in three patients with rheumatoid arthritis (RA) had metabolic syndrome (MetS), with a pooled prevalence of 30.3%. 

Meta-regression identified waist circumference, BMI, triglycerides, and fasting glucose as major contributors, while higher HDL levels were protective. 

These findings underscore the strong link between chronic inflammation and cardiometabolic risk in RA, highlighting the need for routine metabolic screening and comprehensive cardiovascular risk management in this population.

Source: BMC Rheumatology | [Read Full Story](https://bmcrheumatol.biomedcentral.com/articles/10.1186/s41927-025-00572-1)

One in Three Rheumatoid Arthritis Patients Has Metabolic Syndrome

In patients with anterior circulation large-vessel occlusion stroke treated with intravenous thrombolysis (IVT) plus endovascular therapy (EVT), shorter thrombolysis-to-recanalization time (TRT) was strongly associated with better outcomes. 

Among those achieving complete reperfusion, patients with TRT ≤ 170 minutes had significantly higher rates of favorable 90-day recovery (70.7% vs 50.6%; aOR 2.92) and excellent outcomes (59.8% vs 40%; aOR 2.86). 

A linear relationship between shorter TRT and improved outcomes was confirmed, emphasizing the importance of minimizing TRT to optimize the benefits of bridging IVT + EVT in acute ischemic stroke.

Source: Springer Nature Link | [Read Full Story](https://link.springer.com/article/10.1007/s00415-025-13440-2)