A cholesterol-lowering diet rich in fiber, legumes, seeds, and monounsaturated fats—while low in saturated fat, cholesterol, and glycemic load—significantly cuts female cancer risk. 

High adherence reduced risks by 26% for breast (OR 0.74), 52% for endometrial (OR 0.48), and 23% for ovarian cancer (OR 0.77). 

Each point on the 7-point score lowered risks by 13%, 20%, and 10%, highlighting such diets as a preventive strategy.

Source: BJOG | [Read Full Story](https://obgyn.onlinelibrary.wiley.com/doi/10.1111/1471-0528.18302?af=R)

Cholesterol-Lowering Diet Linked to Reduced Risk of Hormone-Related Cancers in Women

In laryngectomy patients, hypothyroidism (19.3%) substantially raises the risk of postoperative wound complications, particularly pharyngocutaneous fistula (PCF). 

Patients with hypothyroidism were nearly three times more likely to develop PCF (OR 2.85), with the risk soaring to over sevenfold when hypothyroidism developed postoperatively (OR 7.69). 

Overall wound complications were also significantly higher (OR 2.48). 

These findings underscore the need for routine thyroid function screening and proactive management protocols for laryngectomy patients to mitigate wound-healing complications. 

Source: Wiley Online Library | [Read Full Story](https://onlinelibrary.wiley.com/doi/10.1002/lary.32324?af=R)

Hypothyroidism Significantly Raises Wound Complication Risk After Laryngectomy

In post–cardiac surgery patients, tissue perfusion pressure (TPP = MAP − critical closing pressure) outperformed mean arterial pressure (MAP) in predicting acute kidney injury (AKI). 

**Key Findings:**
- AKI occurred in 17.6%, tripling major morbidity (45.1% vs 14.2%) and raising mortality nearly eightfold (15.8% vs 2.0%). 
- TPP < 38 mmHg raised AKI risk (OR 1.75; 1.69 with vasopressors). 

A high-risk phenotype (TPP 35.6 mmHg) saw ~1 in 3 develop AKI, highlighting TPP as a key hemodynamic target.


Source: Science Direct | [Read Full Story](https://www.sciencedirect.com/science/article/abs/pii/S0022522325005653?dgcid=rss_sd_all)

Low Perfusion Pressure Linked to Higher AKI Risk After Cardiac Surgery

In patients with cholelithiasis and difficult common bile duct stones (DCBDS), a single-stage approach—laparoscopic CBD exploration with cholecystectomy (LCBDE + LC)—outperformed the two-stage endoscopic retrograde cholangiopancreatography with subsequent cholecystectomy (ERCP + LC) strategy. 

Though CBD clearance was similar, LCBDE + LC halved residual stones, cut complications fourfold, and eliminated postoperative pancreatitis and hyperamylasemia. 

Cholangitis risk was 3.5 times lower, with shorter hospital stays, quicker bowel recovery, reduced inflammation, and better liver function, supporting it as the safer, more efficient option.

Source: Science Direct | [Read Full Story](https://www.sciencedirect.com/science/article/abs/pii/S1091255X2500215X?dgcid=rss_sd_all)

Single-Stage Laparoscopic Approach Outperforms ERCP for Difficult Bile Duct Stones

Analyzing adults with chronic, ≥moderate-to-severe aortic regurgitation (AR) reveals that atrial fibrillation (AF) significantly heightens mortality risk. 

AF was linked to a 2-fold increase in all-cause death after adjusting for age, comorbidities, left ventricular volumes, left atrial size, and pulmonary pressures (HR up to 2.21). 

The study also included substantial rates of hypertension (46%) and bicuspid aortic valve (36%). 

With nearly one in six AR patients affected, the findings underscore the potential need to treat AF not merely as a comorbidity but as a possible trigger for earlier surgical intervention. 

Source: BMJ Journals | [Read Full Story](https://heart.bmj.com/content/early/2025/07/16/heartjnl-2025-325823?rss=1)

Atrial Fibrillation Doubles Mortality Risk in Significant Aortic Regurgitation

A study of 29,851 children with corticosteroid-treated asthma shows that metabolic dysfunction in kids and parents heightens the asthma burden. 

**Key Findings:**
- Among them, 1,430 had severe asthma, 4,750 had poor control, and 2,353 had exacerbations. 
- Elevated LDL in children raised severe asthma odds 2.2-fold, while high triglycerides and low HDL increased exacerbation and poor control odds ~1.5-fold. 
- Maternal dyslipidemia and HbA1c raised uncontrolled asthma risk 1.2–1.4-fold; paternal HbA1c linked to exacerbations. 

Findings highlight lipid screening for at-risk families.

Source: BMC | [Read Full Story](https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-025-03321-7)

Parental Dyslipidemia Emerges as a Hidden Driver of Pediatric Asthma Burden

Changes in metabolic dysfunction-associated steatotic liver disease (MASLD) status significantly impact risks of type 2 diabetes, cardiovascular disease, and mortality, according to a study of 4 million adults. 

**Key Findings:**
- Persistent MASLD (fatty liver index ≥ 60) raised T2DM risk fivefold (HR: 5.28). 
- Incident and regressed MASLD also posed elevated risks (HR: 3.30, 2.87). 
- In 636,520 individuals with T2DM, persistent MASLD increased heart failure (HR: 1.28), myocardial infarction (HR: 1.15), stroke (HR: 1.14), and mortality (HR: 1.11). 

Findings highlight MASLD’s crucial role in metabolic and cardiovascular outcomes.

Source: BMC | [Read Full Story](https://cardiab.biomedcentral.com/articles/10.1186/s12933-025-02824-3)

Prolonged MASLD Duration Exacerbates Risks of Diabetes and Cardiovascular Events

Critically ill patients with autoimmune diseases (AIDs) are at significantly higher risk of developing delirium in the ICU. 


Delirium occurred in nearly 30% of study participants, with AID patients facing more than double the risk compared to non-AID counterparts after multivariate adjustment (HR: 2.171). 

This elevated risk persisted even after rigorous propensity score matching (PSM-adjusted HR: 2.376) and inverse probability of treatment weighting (IPTW-adjusted HR: 2.365). 

These findings spotlight the urgent need for intensified delirium monitoring and early cognitive intervention strategies in ICU patients with autoimmune conditions.

Source: Frontiers | [Read Full Story](https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1621441/full)

Autoimmune Diseases Double Delirium Risk in ICU Patients

Persistent prediabetes significantly raises the risk of developing pancreatic cancer by 28% compared to individuals with stable normoglycemia (aHR 1.28). 

Interestingly, those who reversed their prediabetic status saw no significant increase in cancer risk (aHR 1.02), highlighting the potential benefits of early glycemic control. 

Over a median follow-up of 6.4 years, 7,698 participants developed pancreatic cancer, with similar trends observed across sexes. 

These findings suggest that reversing prediabetes could be a key strategy in mitigating the rising burden of pancreatic cancer.

Source: Science Direct | [Read Full Story](https://www.sciencedirect.com/science/article/abs/pii/S0749379725004702?dgcid=rss_sd_all)

Persistent Prediabetes Increases Pancreatic Cancer Risk by 28%

Women face greater smoking-related COPD risks than men. Female smokers with ≥50 pack-years had 41.6x higher exacerbation risk vs never-smokers (23.7-fold increase in males). 

**Key Findings:**
- Respiratory mortality HRs reached 11.1 in women vs 5.66 in men. 
- Smoking also disproportionately increased women’s risks of airway obstruction, chronic bronchitis, and dyspnea. 

Findings highlight the urgent need for sex-specific prevention strategies.

Source: BMJ Journals | [Read Full Story](https://thorax.bmj.com/content/80/8/512?rss=1)