In a cohort of 2,530 critically ill patients with pulmonary hypertension (PH), acidosis emerged as a strong predictor of in-hospital mortality. 

**Key Findings:**
- Of 247 deaths, those with acidosis had markedly worse outcomes, with logistic regression showing high mortality risk (OR 5.53, 5.56, and 2.19 across adjusted models), independent of factors like sepsis and renal function. 
- Subgroup analyses confirmed acidosis as a stable risk factor, underscoring the importance of vigilant acid–base monitoring and timely intervention in PH patients to improve survival outcomes.

Source: Frontiers | [Read Full Story](https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1654432/full)

Acidosis Strongly Predicts Death in Pulmonary Hypertension Patients

A multicenter study of 40,001 patients with nasal symptoms across 19 Indian states found allergic rhinitis (AR) in 53.7% using the SFAR questionnaire, underscoring its high burden. 

Sneezing was most common (69.1% overall; 86.8% in AR-positive), with house dust mites as the leading allergen (73.8%). 

Symptoms peaked from October to January, and nearly 50% reported a family history of asthma, eczema, or AR. Yet, fewer than half had a doctor-confirmed diagnosis, and only 31.5% underwent allergy testing. 

These findings highlight the underdiagnosis of AR in India and support SFAR as a practical screening tool for early detection and management.

Source: Dovepress | [Read Full Story](https://www.dovepress.com/an-indian-cross-sectional-study-to-evaluate-in-clinic-allergic-rhiniti-peer-reviewed-fulltext-article-JAA)

High Burden of Allergic Rhinitis Uncovered Across India

A nationwide study found higher 5-year risks of cardiovascular (19.3% vs. 17.1%) and cerebrovascular disease (25.7% vs. 23.9%) in patients undergoing total knee arthroplasty (TKA) compared with controls. 

**Key Findings:**
- Moderate-to-vigorous activity ≥5 times weekly reduced cardiovascular risk by 8% (HR 0.918) and cerebrovascular risk by 11% (HR 0.890). 
- Previously inactive patients who became active gained significant benefit, while those who stopped exercising after TKA faced sharply increased cerebrovascular risk. 

These results highlight the importance of maintaining or initiating regular physical activity after TKA to improve long-term outcomes.

Source: The Journal of Bone and Joint Surgery | [Read Full Story](https://journals.lww.com/jbjsjournal/abstract/9900/maintaining_or_increasing_physical_activity_is.1558.aspx)

Staying Active After Knee Replacement Lowers Heart and Stroke Risk

In non-small cell lung cancer (NSCLC) patients undergoing anatomical resection, severe COPD (GOLD III–IV) was linked to higher postoperative complications, including prolonged ventilation, air leaks, and arrhythmias, compared with mild/moderate COPD (GOLD I–II). 

Median overall survival was significantly shorter in severe COPD (43.7 vs. 85.3 months). 

Independent predictors of reduced survival included severe COPD (HR 1.6), advanced tumor stage (pT3–4, HR 1.3), nodal involvement (pN1–2, HR 2.1), elevated CRP, and low VO₂max. 

These findings underscore COPD severity as a key determinant of perioperative risk and long-term outcomes in operable NSCLC.

Source: Dovepress | [Read Full Story](https://www.dovepress.com/copd-severity-as-an-independent-predictor-of-long-term-survival-in-ope-peer-reviewed-fulltext-article-COPD)

Severe COPD Predicts Poor Survival and Complications After Lung Cancer Surgery

In young adults (≤50 years) undergoing percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS), 10.4% were on dialysis and faced significantly worse outcomes. 

**Key Findings:**
- Compared to non-dialysis patients, they had longer hospital stays (4 vs. 2 days), higher major bleeding (10.8% vs. 2.3%), and increased one-year major adverse cardiovascular events (MACE) (26.2% vs. 9.8%). 
- All-cause mortality (13.9% vs. 3.4%) and recurrent MI (13.9% vs. 6.4%) were also higher. 
- Dialysis independently predicted elevated MACE (HR 2.7) and long-term mortality (HR 4.9). 

These findings emphasize the need for tailored preventive strategies and careful management in young dialysis patients undergoing PCI.

Source: The American Journal of Cardiology | [Read Full Story](https://www.ajconline.org/article/S0002-9149(25)00507-7/abstract?rss=yes)

Dialysis Linked to Higher Risk and Mortality After PCI in Young ACS Patients

A meta-analysis found cardiac arrhythmias in 15% of patients hospitalized with acute exacerbations of chronic obstructive pulmonary disease (AECOPD), with higher prevalence in older adults and developed countries. 

Advanced age and elevated CRP were key risk factors, while long-acting beta-agonists (LABAs) lowered arrhythmia risk (OR 0.42). 

Arrhythmias tripled in-hospital mortality risk (RR 3.33), with atrial fibrillation further increasing death risk (RR 3.70). 

These findings highlight the prognostic impact of arrhythmias in AECOPD and support routine ECG monitoring and personalized risk assessment to improve patient outcomes.

Source: BMC | [Read Full Story](https://www.dovepress.com/prevalence-and-risk-factors-of-arrhythmias-in-patients-with-acute-exac-peer-reviewed-fulltext-article-COPD)

Arrhythmias Amplify Short-Term Mortality in Acute COPD Exacerbations

In a neonatal ICU study of very-low-birth-weight infants, 44.7% developed hyperglycemia (>150 mg/dL), which was linked to higher risks of retinopathy of prematurity (ROP) and intraventricular hemorrhage (IVH) compared with normoglycemic infants. 

Prolonged hyperglycemia (>72 h) significantly increased ROP risk, while severe hyperglycemia (≥220 mg/dL) independently raised IVH risk. 

These findings highlight the importance of strict glucose monitoring and control in this high-risk population to reduce neurological and ophthalmological complications.

Source: BMC Pediatrics | [Read Full Story](https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-025-06035-3)

Hyperglycemia Raises Risk of Eye and Brain Complications in Very-Low-Birth-Weight Infants

In an analysis of 3,248 women, magnesium intake was linked to lower migraine risk in pre-menopausal women. 

**Key Findings:**
- Migraine prevalence was 31.3% in pre-menopausal versus 15.6% in post-menopausal women. 
- Among pre-menopausal women, each unit increase in magnesium intake below 325.41 mg/day reduced migraine odds by 36% (OR 0.64), though no added benefit was seen above this threshold. 

These findings suggest menopausal status modifies the magnesium–migraine relationship and highlight the potential value of targeted magnesium supplementation in reproductive-age women, given widespread dietary insufficiency.

Source: Dovepress | [Read Full Story](https://www.dovepress.com/association-between-magnesium-intake-and-migraine-among-pre-and-postme-peer-reviewed-fulltext-article-IJWH)

Magnesium Intake Reduces Migraine Risk in Pre-Menopausal Women

In patients with type 2 diabetes, higher nocturnal hypoxemic burden—measured as time spent with oxygen saturation <90% (T90)—was strongly linked to future kidney decline. 

Those in the highest T90 quartile had nearly a threefold greater risk of developing very-high-risk chronic kidney disease (CKD) compared to the lowest quartile (OR 2.96), independent of traditional risk factors. 

Progression to severe CKD occurred in 15% of high T90 patients versus 6.2% in others, underscoring nocturnal hypoxemia as a powerful and novel prognostic marker for diabetic kidney disease progression.

Source: BMC | [Read Full Story](https://cardiab.biomedcentral.com/articles/10.1186/s12933-025-02918-y)

Nocturnal Oxygen Drops Signal Rapid CKD Risk in Type 2 Diabetes

In a study of 1,200 cardiovascular patients with implantable cardioverter-defibrillators (ICDs) and baseline potassium ≤4.3 mmol/L, actively raising plasma potassium to the high-normal range (4.5–5.0 mmol/L) over 39.6 months significantly reduced adverse outcomes. 

The high-normal group had a 24% lower risk of the composite endpoint of ventricular arrhythmias, arrhythmia/heart failure hospitalizations, or all-cause mortality compared to standard care (22.7% vs. 29.2%; HR 0.76), largely driven by fewer sustained ventricular tachycardia and appropriate ICD therapies. 

Hospitalization rates for hyperkalemia or hypokalemia were similar, confirming the safety and tolerability of potassium optimization as a strategy to lower arrhythmic risk.

Source: The New England Journal of Medicine | [Read Full Story](https://www.nejm.org/doi/full/10.1056/NEJMoa2509542?af=R&rss=currentIssue)