19 Nov 2025 • Low bone mineral density signaled higher venous thromboembolism risk in postmenopausal women, according to new data from 511 hospitalized patients.

Women with osteoporosis recorded significantly higher Caprini scores than those with normal bone density (6.20 vs 5.40), alongside increases in D-dimer and fibrinogen as BMD declined. The lowest BMD value independently predicted elevated venous thromboembolism risk (OR 0.02), and BMD showed a clear inverse correlation with Caprini scoring.

Findings suggest incorporating bone density into existing risk models may improve venous thromboembolism stratification and support targeted thromboprophylaxis in women with low bone mineral density.

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