27 Oct 2025 • Infants with congenital heart disease (CHD) were nearly six times more likely to experience seizures than those without CHD (aOR 5.7), according to a US national analysis.

Mortality was also significantly higher in CHD infants who developed seizures (8.5% vs 1.1%; aOR 3.6), along with longer hospital stays. Single-ventricle physiology (3.2%) carried the highest risk, trailed by left-sided CHD (1.9%), shunt lesions (1.8%), and cyanotic CHD (1.2%).

Male sex, maternal hypertension, sepsis, acute kidney injury, stroke, and ECMO support further increased seizure risk. Early neurologic monitoring is crucial to detect and manage these high-risk cases.

Source: Journal of the American Heart Association | Read Full Story