6 Oct 2025 • A large cohort study of 381,000 adults followed for a median of 15.5 years found that hemorrhoidal disease (HD) was associated with a significantly higher risk of dementia.

Overall, 22.5% (80,488 cases) developed dementia, and even after propensity score matching, HD was linked to a 24% greater risk (HR 1.243) compared to those without HD.

Interestingly, patients who underwent surgical or procedural treatment for HD had a reduced dementia risk (HR 0.925).

Researchers suggest that while hemorrhoids may not directly cause dementia, they could signal underlying systemic processes—such as chronic inflammation or vascular dysfunction—contributing to cognitive decline.

Source: Frontiers | Read Full Story