12 Aug 2025 • In women with cerebral arteriovenous malformations (AVMs), pregnancy raises rupture risk to 4.5% vs 1.6% in non-pregnant periods (RR 3.1), with peak danger in the 2nd and 3rd trimesters.

Key predictors include adolescent (≤19) or advanced-age (≥35) pregnancy (OR 8.32), prior rupture (OR 4.20), diffuse nidus morphology (OR 2.32), and multifetal gestation (OR 18.31).

Findings highlight pregnancy—especially at extreme maternal ages or with multiple fetuses—as a high-risk period, underscoring the need for individualized monitoring and delivery planning.

Source: Wiley Online Library | Read Full Story