6 Oct 2025 • A recent study of twin pregnancies revealed that maternal subclinical hypothyroidism (SCH) markedly increased the risk of birth weight discordance.

Key Findings:

• SCH was present in 45.3% of women, while 43.4% of twin pairs showed growth discordance.
• Larger twins were more often male, taller, and had greater head circumference.
• Mothers with SCH had higher rates of discordance and greater intertwin weight differences.

Logistic regression identified SCH as an independent risk factor (OR 1.601–9.425), and linear analysis confirmed a positive association with the extent of weight difference, suggesting SCH as a key contributor to asymmetric fetal growth in twin gestations.

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