Hypertension Emerges as Key Metabolic Driver of Postpartum Depression Risk
12 Aug 2025 • An analysis shows a causal link between metabolic syndrome components—particularly hypertension—and postpartum depression (PPD) risk.
Key Findings:
- Genetically predicted hypertension increased PPD odds by 48% (OR 1.48), and larger waist circumference raised risk by 18% (OR 1.18), while higher fasting glucose lowered risk (OR 0.69).
- Reverse analysis suggested PPD may reduce HDL-C (OR 0.96/unit).
Multivariable analysis confirmed hypertension as the main driver, highlighting the need for blood pressure monitoring during pregnancy and postpartum to help prevent PPD.
Source: International Journal of Gynecology & Obstetrics | Read Full Story