25 Jul 2025 • In 7,672 virologically suppressed people with HIV, switching from three-drug therapy (3DR) to a two-drug regimen (2DR) proved safe and potentially advantageous over three years.

Only 8.2% used 2DR, but they had a lower risk of major events—cardiovascular disease, cancer, or death—than those on 3DR (2.55% vs. 4.69%), a 2.15% absolute reduction, mainly from fewer non-AIDS cancers and deaths.

Findings support 2DR as a viable, health-protective option for stable patients.

Source: The Lancet | Read Full Story