5 Nov 2025 • A large study of 116,000 adults with type 1 or type 2 diabetes without known heart failure (HF) found that elevated natriuretic peptide (NP) levels strongly predicted future HF and mortality.

Key Findings:

• Approximately 40% of patients had a B-type natriuretic peptide (BNP) level of 50 pg/mL or higher, and a similar proportion had N-terminal pro–B-type natriuretic peptide (NT-proBNP) levels of 125 pg/mL or higher.
• In patients with NT-proBNP levels between 125 and 300 pg/mL, the risk of developing HF or death was doubled in type 1 diabetes (HR 2.04) and increased by 85% in type 2 diabetes (HR 1.85).
• Patients with NT-proBNP levels above 300 pg/mL had a four-fold higher risk of HF or death in type 1 diabetes (HR 4.48) and a three-fold higher risk in type 2 diabetes (HR 3.58).
• BNP showed comparable prognostic performance to NT-proBNP in predicting HF and mortality.

Routine NP measurement can uncover subclinical cardiac dysfunction and guide early preventive interventions in diabetic patients.

Source: Diabetes Care | Read Full Story