23 Jul 2025 • A large study uncovers a bidirectional link between autoimmune liver diseases (AILD) and diabetes.

Key Findings:

• Genetically predicted primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) raised type 1 diabetes (T1DM) risk (OR 1.41, 1.39), while PBC modestly increased type 2 diabetes (T2DM) risk (OR 1.03).
• Conversely, T1DM elevated risks of PBC (OR 1.28), PSC (1.27), and autoimmune hepatitis (1.13).

The PBC–T2DM association weakened after BMI and IBD adjustment, stressing shared pathways and the need for diabetes screening in AILD patients.

Source: Wiley Online Library | Read Full Story