4 Jul 2025 • A long-term study of Crohn’s disease patients has shown that developing one extraintestinal manifestation (EIM)—such as oral ulcers, joint pain, or skin lesions—raises the likelihood of developing additional EIMs over time.

Among patients followed for up to 25 years, the prevalence of EIMs rose from 21% at diagnosis to 47% by the end of follow-up.

Oral ulcers commonly co-occurred with other EIMs. Joint involvement and skin lesions were most frequent.

Strong associations were found between common manifestations like peripheral arthritis and others, including axial spondyloarthropathy, ocular involvement, and thromboembolism.

The findings highlight the need for early detection and monitoring of EIM clusters in Crohn’s disease.

Source: Science Reports | Read Full Story