4 Jul 2025 • Larger uterine volume before pregnancy may raise the risk of preterm birth in women with adenomyosis, according to a retrospective cohort study. Among singleton pregnancies, those who delivered preterm had significantly greater uterine volumes (median 108.9 cm³ vs. 85.3 cm³).

Each 10 cm³ increase in uterine size raised the odds of preterm birth by 36–40%, with an inflection point of 89.3 cm³.

The association was stronger in focal than diffuse adenomyosis (OR 1.43 vs 1.10). Conditions like preterm premature rupture of membrane (28.1% vs 14.3%), placental malposition (32.6% vs 8.9%), and preeclampsia (13.5% vs 5.2%) were also more frequent in preterm cases.

These findings suggest uterine volume may be a risk marker for early monitoring and intervention in adenomyosis-related pregnancies.

Source: BMC Pregnancy and Childbirth | Read Full Story