17 Jul 2025 • Changes in metabolic dysfunction-associated steatotic liver disease (MASLD) status significantly impact risks of type 2 diabetes, cardiovascular disease, and mortality, according to a study of 4 million adults.

Key Findings:

• Persistent MASLD (fatty liver index ≥ 60) raised T2DM risk fivefold (HR: 5.28).
• Incident and regressed MASLD also posed elevated risks (HR: 3.30, 2.87).
• In 636,520 individuals with T2DM, persistent MASLD increased heart failure (HR: 1.28), myocardial infarction (HR: 1.15), stroke (HR: 1.14), and mortality (HR: 1.11).

Findings highlight MASLD’s crucial role in metabolic and cardiovascular outcomes.

Source: BMC | Read Full Story