28 Jul 2025 • An analysis of 16,324 participants shows high-sensitivity C-reactive protein (hs-CRP) > 2.5 mg/L is linked to a 65% higher risk of diabetic nephropathy (DN) (OR 1.65), with stronger association in cohort studies (OR 2.15) and smaller studies (OR 2.04).

hs-CRP also correlates with urinary albumin excretion and microvascular complications, reinforcing its value as a predictive biomarker.

Despite high heterogeneity (I² = 79.4%), findings spotlight inflammation’s key role in DN progression and support hs-CRP for early risk stratification and as a target for anti-inflammatory strategies in diabetes care.

Source: BMC Nephrology | Read Full Story