In a study of hospitalized exacerbation of chronic obstructive pulmonary disease (ECOPD) patients, 17% experienced treatment failure, defined as therapy escalation or in-hospital death. 

Key predictors included home oxygen therapy (OR 5.34), neutrophil count ≥7000/μL (OR 3.55), and acidemia (OR 3.13). Among those on narrow-spectrum antibiotics, failure was significantly higher in patients receiving home oxygen. 

The findings underscore the need for early risk identification and tailored treatment, including broader antimicrobial coverage for high-risk patients.

Source: Dovepress | [Read Full Story](https://www.dovepress.com/factors-associated-with-initial-treatment-failure-in-inpatients-with-e-peer-reviewed-fulltext-article-COPD)