A large study of 10,889 adults with diabetes or prediabetes reveals a striking U-shaped relationship between the Glycated Hemoglobin Index (HGI) and cardiovascular disease (CVD) risk. 

**Key Findings:**
- Researchers found that both low and high HGI values were associated with elevated risks of CVD, heart attack, and congestive heart failure (CHF). 
- Each unit rise in HGI was linked to significantly higher odds of CVD (OR: 1.34), heart attack (OR: 1.34), and CHF (OR: 1.39). 

These findings position HGI as a promising early marker for cardiovascular risk stratification in dysglycemic populations.

Source: BMC | [Read Full Story](https://dmsjournal.biomedcentral.com/articles/10.1186/s13098-025-01754-0)