21 Jan 2026 • New analysis from the SPRINT trial showed that prediabetes substantially amplified heart failure (HF) risk when accompanied by subclinical myocardial injury or stress in adults with hypertension.

Key Findings:

• Among 8,234 participants followed for a median of 3.2 years, those with prediabetes and elevated high-sensitivity cardiac troponin I (≥6 ng/L in men, ≥4 ng/L in women) had over four times the risk of HF compared with individuals with normal glucose levels and no evidence of injury (HR 4.20).
• Risk rose further when prediabetes coexisted with myocardial stress, reflected by elevated N-terminal pro–B-type natriuretic peptide levels of at least 125 pg/mL (HR 5.20).
• Longitudinal findings supported these results: participants with prediabetes who experienced a 25% or greater increase in troponin or NT-proBNP within 12 months faced a two- to threefold higher HF risk (HR 3.05 and HR 2.39, respectively).

The data suggested that integrating glycemic status with cardiac biomarker trends may help identify hypertensive patients at high HF risk earlier.

Source: JAMA Network | Read full story