6 Oct 2025 • In pregnant women hospitalized for threatened preterm labor, preterm premature rupture of membranes, or cervical insufficiency, abnormal cervicovaginal flora (CVF), especially bacterial dominance, was linked to worse perinatal outcomes.

While 64.8% had Lactobacillus-dominated normal flora, those with bacterial CVF had the highest preterm birth rates and composite adverse perinatal outcomes (CAPO, 52.5%), with the lowest mean birth weights.

A cervical length ≤28.5 mm predicted CAPO with 70.7% sensitivity and 71.1% specificity (AUC 0.763), highlighting the value of CVF profiling and cervical length monitoring in predicting neonatal risk.

Source: BMC Pregnancy and Childbirth | Read Full Story