19 Aug 2025 • A study of 1,091 patients with cardiogenic shock (CS) identified glycemic variability (GV)—fluctuations in blood glucose—as a strong, independent predictor of 28-day mortality, regardless of diabetes status.

Key Findings:

• Patients were grouped into tertiles (GV1 <16.2%, GV2 16.2–25.3%, GV3 >25.3%), with the highest GV group showing a 42% higher risk of death (HR 1.42).
• Mortality risk was greatest in diabetics with severe GV (HR 1.53), but non-diabetics with high GV were also vulnerable (HR 1.30).

These findings establish GV thresholds for risk stratification in CS and stress the need for glucose-monitoring and GV-targeted interventions in critical care.

Source: Science Direct | Read Full Story